Giant-cell reparative granuloma of the mandible.

Discussion Giant cell reparative granuloma is an uncommon lesion that is a reactive process and not a neoplasm. At histologic analysis, giant cell reparative granulomas demonstrate plump, bland fibroblasts and multinucleated giant cells surrounding foci of hemorrhage; osteoid production along hemorrhagic foci is commonly seen. The histologic appearance of GCRG is similar to that of brown tumor of hyperparathyroidism. GCRG occurs in patients in the 2nd and 3rd decades of life and has a predilection for the mandible and maxilla. Jaw lesions affect women more frequently than men (2:1 ratio). Patients present with pain and swelling; hormonal stimulation of pregnancy may lead to significant enlargement.